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SysMedSUDs – A systems-medicine approach towards distinct and shared resilience and pathological mechanisms of substance use disorders
The interdisciplinary SysMedSUDs consortium employs a systems-level approach to investigate epigenetic, transcriptomic and neurochemical commonalities and differences across substance use disorders to characterize the complex resilience and pathomechanisms of these diseases. As part of the subproject SP5 ("Examining the excitatory/inhibitory (E/I) neurotransmitter balance using magnetic resonance spectroscopy in patients with substance use disorders"), researchers in Berlin and Mannheim are investigating the relationship between the neurotransmitters glutamate and GABA in two key brain regions of the addiction cycle in patients with nicotine, cannabis or opiate addiction as well as healthy controls and analyze how this relationship affects large-scale resting-state brain network properties.
Members Berlin: Justin Böhmer
Head of subproject: Henrik Walter (with Andreas Heinz, Wolfgang Sommer, Gabriele Ende, Falk Kiefer) within the research consortium SysMedSUDs: A systems-medicine approach towards distinct and shared resilience and pathological mechanisms of substance use disorders (speaker: Rainer Spanagel, Mannheim, Germany)