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Personality and underlying brain networks (Amsterdam UMC)

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Personality and underlying brain networks (Amsterdam UMC)

In this project, we investigate whether personality traits and their associated neural substrates represent unique brain-based endophenotypes that can be used to predict and extrapolate individual behaviors. In addition, we are investigating whether these neural substrates contribute to the identification of clinically relevant mechanisms in psychiatric disorders. This idea is based on three core assumptions: First, a person's personality profile can be described as consistent across time and situations, providing the basis for stable human behavioral responses to broad classes of environmental stimuli. Second, information about a person's personality is deeply engraved ("encoded") in the large-scale mesoscopic interactions of brain regions (i.e., the connectome). Third, dysfunctional personality profiles represent a wide-ranging vulnerability factor for severe, chronic, or recurrent poly-symptomatic psychopathology and are significantly related to its severity and psychopathological development. Personality-associated brain biomarkers may therefore hold promise for accurate and reliable prediction in the clinical setting, contributing to the development of a personality-centered model of psychopathological disorders. This project is in collaboration with the "Multiscale Network Neuroscience" lab (Amsterdam UMC):

Head: Dr. Linda Douw, Dr. rer. medic. J. Kruschwitz, habil., Dipl.-Psych. (CCM) 
contact: Dr. rer. medic. J. Kruschwitz, habil., Dipl.-Psych. (CCM)